How cancer cells avoid cell death

June 21, 2013 ? A new study by a team of researchers from the University of Notre Dame provides an important new insight into how cancer cells are able to avoid the cell death process. The findings may suggest a chemotherapeutic approach to prevent the spread of cancers.

Metastasis, the spread of cancer from one organ to other parts of the body, relies on cancer cells ability to evade a cell death process called anoikis, according to Zachary T. Schafer, Coleman Assistant Professor of Cancer Biology at Notre Dame. Metalizing cancer cells are able to survive anoikis, which normally results from detachment from the extracellular matrix. However, Schafer notes that the molecular mechanisms cancer cells detached from the extracellular matrix use to survive has not been well understood.

"This paper reveals that cancer cells that are detached from their normal environment, as they would be during metastasis, relay on the activity of antioxidant enzymes to facilitate their survival," Schafer said. "This class of enzymes is critical for neutralizing oxidative stress and function much like the compounds that are present in a variety of foods."

The paper describes a prominent role for antioxidant enzymes in facilitating the survival of breast cancer cells after detachment from the extracellular matrix. Conversely, the researchers report, silencing antioxidant enzyme expression reduced tumor formation.

"The results in this paper suggest that targeting antioxidant enzymes with novel therapeutics may selectively kill off metastasizing cancer cells," Schafer said.

The paper appears in the journal Cancer Research, which is the most frequently cited cancer journal in the world.

The researchers collaborated with Matthew Leevy in Notre Dame's in vivo imaging facility.

Other authors of the paper include doctoral student Calli Davison, rising junior Sienna Durbin, 2011 alum Matthew Thau, graduate student Victoria Zellmer, and Sarah Chapman, Justin Diner and Connor Wathen from the Notre Dame Integrated Imaging Facility.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/sSIam7aQM7s/130621141806.htm

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Opinion: Why we need government surveillance (CNN)

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Channing Tatum & Jenna Dewan-Tatum Welcome Baby Girl!

Channing Tatum & Jenna Dewan-Tatum Welcome Baby Girl!

Jenna Dewan-Tatum and her hunky husband Channing Tatum have welcomed their first child in London, where the actor is filming his latest movie. The “Step Up 2″ actress gave birth at a private London hospital on Thursday. Jenna, 32, gave birth on Thursday, with reports surfacing on Monday that they had a baby girl! The ...

Channing Tatum & Jenna Dewan-Tatum Welcome Baby Girl! Stupid Celebrities Gossip Stupid Celebrities Gossip News

Source: http://stupidcelebrities.net/2013/06/channing-tatum-jenna-dewan-tatum-welcome-first-child/

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Real Estate Sampler: 8 Readers' Houses For Sale

Thanks Julia.
I asked the agent who listed our primary home, last year, if I could do the photos for our home listing. She said she would like to see a couple of my photos. I emailed them. She answered right back to me, asking for many more.:-) That listing was very nice, plus they did a slideshow with music. I recommend you ask about doing your own photos or maybe hire someone who specializes in real estate photography.

When J was diagnosed with Parkinson?s last Fall, we decided to take the house of the market at the end of the contract time, so we could devote our time to learning more about Parkinson?s Disease and see how things would go for J. Well?we are now considering marketing the house again. We want to see what happens with the condo first.

Reply

Source: http://hookedonhouses.net/2013/06/01/real-estate-sampler-8-readers-houses-for-sale/

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Agricultural fires in western Mexico

Public release date: 31-May-2013
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Contact: Rob Gutro
robert.j.gutro@nasa.gov
NASA/Goddard Space Flight Center

The Moderate Resolution Imaging Spectroradiometer (MODIS) on NASA's Aqua satellite detected dozens of fires burning in western Mexico on May 30, 2013. The fires are outlined in red.

The location, widespread nature, and number of fires suggest that these fires were deliberately set to manage land. Farmers often use fire to return nutrients to the soil and to clear the ground of unwanted plants. While fire helps enhance crops and grasses for pasture, the fires also produce smoke that degrades air quality. Although the smoke hits hardest right around the area being burned, a fair amount of it drifts. News outlets in Texas, including NBC affiliate KCBD, report haze over the area and add "the smoke is prevalent from late March through early June. If smoke arrives here, it will likely affect those with respiratory conditions such as asthma."

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NASA image courtesy Jeff Schmaltz LANCE/EOSDIS MODIS Rapid Response Team, GSFC. Caption by Lynn Jenner.

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 31-May-2013
[ | E-mail | Share ]

Contact: Rob Gutro
robert.j.gutro@nasa.gov
NASA/Goddard Space Flight Center

The Moderate Resolution Imaging Spectroradiometer (MODIS) on NASA's Aqua satellite detected dozens of fires burning in western Mexico on May 30, 2013. The fires are outlined in red.

The location, widespread nature, and number of fires suggest that these fires were deliberately set to manage land. Farmers often use fire to return nutrients to the soil and to clear the ground of unwanted plants. While fire helps enhance crops and grasses for pasture, the fires also produce smoke that degrades air quality. Although the smoke hits hardest right around the area being burned, a fair amount of it drifts. News outlets in Texas, including NBC affiliate KCBD, report haze over the area and add "the smoke is prevalent from late March through early June. If smoke arrives here, it will likely affect those with respiratory conditions such as asthma."

###

NASA image courtesy Jeff Schmaltz LANCE/EOSDIS MODIS Rapid Response Team, GSFC. Caption by Lynn Jenner.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-05/nsfc-afi053113.php

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Zumba instructor gets 10 months for prostitution

ALFRED, Maine (AP) ? A high-profile prostitution scandal featuring sex videos, adultery, exhibitionism and more than 100 clients drew to a close Friday when a Zumba fitness instructor who turned her studio into a brothel was sentenced to 10 months in jail.

Alexis Wright was sentenced under a plea agreement to 20 counts including prostitution, conspiracy, tax evasion and theft by deception.

Justice Nancy Mills extended wishes for success after the sentence was imposed.

"Based on what you have to say and what I know about you from your attorney, I know that you will succeed when you're released and that you will prevail. I wish you success," Mills said.

Wright's attorney said the defendant had a difficult childhood, witnessing domestic violence and suffering sexual abuse, before she met Mark Strong, her eventual business partner. She said Strong used her background to manipulate her.

Addressing the judge through tears, Wright said she felt relief when police raided her business on Feb. 12, 2012, because she wanted out. She said she intends to work when she's released to help other women in similar situations.

"In my eyes I'm free. I free from this. And I have an incredible amount of strength that I knew was in me somewhere. Now that I have the strength I want to encourage others to come forward. I want them to know that there's at least one person out there who'll believe their story, no matter how crazy it seems," she told the judge.

"It's my intention to stand up for what is right. When I'm out, I'm going to pursue helping people fight through situations that are similar to mine. I'm optimistic that something good will come out of this."

Afterward, she was led from court to begin serving her sentence.

The 30-year-old Wright was accused of conspiring with an insurance business owner to run a prostitution business in which she videotaped clients without their knowledge and kept detailed records over an 18-month period indicating she made $150,000 tax-free. She also collected more than $40,000 in public assistance.

The scandal in the seaside town of Kennebunk, known for its sea captain's mansions, beaches and New England charm, became a sensation following reports that Wright had at least 150 clients, some of them prominent. So far, those who have been charged include a former mayor, a high school hockey coach, a minister, a lawyer and a firefighter.

Wright was originally charged with 106 counts. All the counts in the plea agreement were misdemeanors, including three counts relating to welfare and tax fraud that were reduced from felonies.

Under the agreement, prosecutors will seek restitution of $57,280.54. Prosecutors say Wright cooperated with prosecutors and spared the state an expensive trial.

Her business partner, Strong, 57, of Thomaston, was convicted of 13 counts related to promotion of prostitution and was sentenced to 20 days in jail. The married father of two, who has acknowledged having an affair with Wright, was originally charged with 59 counts.

It came as little surprise that Wright opted to avoid standing trial by pleading guilty because evidence against her was overwhelming in Strong's trial, with jurors watching a video of her engaging in sex with a client who left $250, which she pocketed.

Prosecutors say paid sex happened in her studio, apartment and an office, where tenants complained about moaning and groaning.

Electronic evidence was plentiful because the two kept in touch via text, email and Skype, which Wright used to send a live video stream of sex acts to Strong. Videos also showed them speaking openly of ledgers, payments and scheduling.

Evidence unsealed after the trial indicated electronic exchanges in which Wright talked about the business goals: nine clients a week, 45 clients a month. They also openly discussed scheduling, insurance payments, her sexy outfits and clients' preferences. She even appeared to seek advice from Strong after encountering an unhappy client.

Business was running smoothly before it came to an abrupt end.

"I feel like this is going to be a good week," Wright wrote to Strong two days before the arrival of detectives with search warrants on Feb. 14, 2012.

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Follow David Sharp at http://twitter.com/David_Sharp_AP

Source: http://news.yahoo.com/zumba-instructor-gets-10-months-prostitution-134347427.html

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Adam Levine Dating Model Nina Agdal!

Adam Levine Dating Model Nina Agdal!

Singer and coach on “The Voice” Adam Levine has landed himself another supermodel. Levine is dating 21-year-old Danish model Nina Agdal, after splitting with Victoria’s Secret model Behati Prinsloo last year. Adam Levine, 34, has reportedly been dating Nina Agdal since early Spring following his split with Namibian model Behati Prinsloo. A source revealed, “Behati ...

Adam Levine Dating Model Nina Agdal! Stupid Celebrities Gossip Stupid Celebrities Gossip News

Source: http://stupidcelebrities.net/2013/05/adam-levine-dating-model-nina-agdal/

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