Saturday, June 22, 2013

How cancer cells avoid cell death

June 21, 2013 ? A new study by a team of researchers from the University of Notre Dame provides an important new insight into how cancer cells are able to avoid the cell death process. The findings may suggest a chemotherapeutic approach to prevent the spread of cancers.

Metastasis, the spread of cancer from one organ to other parts of the body, relies on cancer cells ability to evade a cell death process called anoikis, according to Zachary T. Schafer, Coleman Assistant Professor of Cancer Biology at Notre Dame. Metalizing cancer cells are able to survive anoikis, which normally results from detachment from the extracellular matrix. However, Schafer notes that the molecular mechanisms cancer cells detached from the extracellular matrix use to survive has not been well understood.

"This paper reveals that cancer cells that are detached from their normal environment, as they would be during metastasis, relay on the activity of antioxidant enzymes to facilitate their survival," Schafer said. "This class of enzymes is critical for neutralizing oxidative stress and function much like the compounds that are present in a variety of foods."

The paper describes a prominent role for antioxidant enzymes in facilitating the survival of breast cancer cells after detachment from the extracellular matrix. Conversely, the researchers report, silencing antioxidant enzyme expression reduced tumor formation.

"The results in this paper suggest that targeting antioxidant enzymes with novel therapeutics may selectively kill off metastasizing cancer cells," Schafer said.

The paper appears in the journal Cancer Research, which is the most frequently cited cancer journal in the world.

The researchers collaborated with Matthew Leevy in Notre Dame's in vivo imaging facility.

Other authors of the paper include doctoral student Calli Davison, rising junior Sienna Durbin, 2011 alum Matthew Thau, graduate student Victoria Zellmer, and Sarah Chapman, Justin Diner and Connor Wathen from the Notre Dame Integrated Imaging Facility.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/sSIam7aQM7s/130621141806.htm

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Monday, June 3, 2013

Channing Tatum & Jenna Dewan-Tatum Welcome Baby Girl!

Channing Tatum & Jenna Dewan-Tatum Welcome Baby Girl!

Jenna Dewan-Tatum & Channing Tatum have babyJenna Dewan-Tatum and her hunky husband Channing Tatum have welcomed their first child in London, where the actor is filming his latest movie. The “Step Up 2″ actress gave birth at a private London hospital on Thursday. Jenna, 32, gave birth on Thursday, with reports surfacing on Monday that they had a baby girl! The ...

Channing Tatum & Jenna Dewan-Tatum Welcome Baby Girl! Stupid Celebrities Gossip Stupid Celebrities Gossip News

Source: http://stupidcelebrities.net/2013/06/channing-tatum-jenna-dewan-tatum-welcome-first-child/

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Real Estate Sampler: 8 Readers' Houses For Sale

Thanks Julia.
I asked the agent who listed our primary home, last year, if I could do the photos for our home listing. She said she would like to see a couple of my photos. I emailed them. She answered right back to me, asking for many more.:-) That listing was very nice, plus they did a slideshow with music. I recommend you ask about doing your own photos or maybe hire someone who specializes in real estate photography.

When J was diagnosed with Parkinson?s last Fall, we decided to take the house of the market at the end of the contract time, so we could devote our time to learning more about Parkinson?s Disease and see how things would go for J. Well?we are now considering marketing the house again. We want to see what happens with the condo first.

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Source: http://hookedonhouses.net/2013/06/01/real-estate-sampler-8-readers-houses-for-sale/

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